Not at all
1) Creates profits for organized crime
So - without drugs, they'll just stop wanting to make easy profit without paying taxes? They'll just improve their behavior, treat others better, and go to work? No. They'll just seek out another means of doing what they want to do.
2) Doesn't reduce substance abuse
Evidence proves the contrary. It's funny that you think legalizing it will reduce substance abuse. Seems highly illogical, and the evidence doesn't point to that.
3) Destroys lives that could be turned around
Drug abuse does that, legal or not.
4) Encourages the militarization of police forces
One of those pure opinion things. People have a low view of law enforcement in general, and seek out one 'cause' to blame. You've chosen this drug issue, someone else would argue it's unfair traffic laws and third would argue it's big brother.
5) Reduces civil liberties in the name of law and order
So here you're arguing it's a civil liberty to use drugs. I see - illogical, and another opinion.
See where we stand - you claim that opinion and myth X, Y, Z are all irrefutable facts, but they're not facts, nor are they irrefutable. See what's happened? Facts have to be supported by evidence, and your evidence isn't there.