Jehovah God’s principal opposer, Satan, is referred to as “the original serpent,” because of his use of the literal serpent in Eden as his means of communication with the woman...
"So down the great dragon was hurled, the original serpent, the one called Devil and Satan, who is misleading the entire inhabited earth; he was hurled down to the earth, and his angels were hurled down with him." Revelation 12:9
He seized the dragon, the original serpent, who is the Devil and Satan, and bound him for 1,000 years." Revelation 20:2
Jesus also classifies other opposers of Jehovah God as “serpents, offspring of vipers"...
“Serpents, offspring of vipers, how will you flee from the judgment of Gehenna?" Matthew 23:33