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Identification of bioactive molecules from tea plant as SARS-CoV-2 main
protease inhibitors
The SARS-CoV-2 main protease enzyme (Mpro) plays a central role in viral replication & thus becomes an attractive target for anti-viral drugs. Inhibition of Mpro causes the virus to die.
In this study, computerized analytical methods were used to identify the 68 molecules with the highest docking energy. of these, a total of 3 molecules were identified as being potent Mpro inhibitors:
Selected bioactive molecules based on -CDOCKER interaction energy.
S. No. Molecules -CDOCKER Interaction Energy
1. Oolonghomobisflavan-A 75.54
2. Theasinensin D 71.58
3. Theaflavin-3′-O-Gallate 71.56
Theasinensin D - Wikipedia
Theaflavin-3-gallate - Wikipedia
oolong homobisflavan A, oolong homobisflavan A Suppliers and Manufacturers at Okchem.com
These are all polyphenol compouds found in Chinese oolong tea. Oolong tea could serve a an inexpensive home remedy for covid-19.
protease inhibitors
The SARS-CoV-2 main protease enzyme (Mpro) plays a central role in viral replication & thus becomes an attractive target for anti-viral drugs. Inhibition of Mpro causes the virus to die.
In this study, computerized analytical methods were used to identify the 68 molecules with the highest docking energy. of these, a total of 3 molecules were identified as being potent Mpro inhibitors:
Selected bioactive molecules based on -CDOCKER interaction energy.
S. No. Molecules -CDOCKER Interaction Energy
1. Oolonghomobisflavan-A 75.54
2. Theasinensin D 71.58
3. Theaflavin-3′-O-Gallate 71.56
Theasinensin D - Wikipedia
Theaflavin-3-gallate - Wikipedia
oolong homobisflavan A, oolong homobisflavan A Suppliers and Manufacturers at Okchem.com
These are all polyphenol compouds found in Chinese oolong tea. Oolong tea could serve a an inexpensive home remedy for covid-19.