Perhaps people should know what is in their E-Juice. I have no problem with requiring that.
Mine contains
Ejuice- Commonly simply referred to as “juice”A consumable liquid that consist of a combination of nicotine, propylene glycol, flavoring, and vegetable glycerin and is available in several different flavors and strengths, this is the stuff that you vaporize.
The acute oral toxicity of propylene glycol is very low, and large quantities are required to cause perceptible health damage in humans; propylene glycol is metabolized in the human body into pyruvic acid (a normal part of the glucose-metabolism process, readily converted to energy), acetic acid (handled by ethanol-metabolism), lactic acid (a normal acid generally abundant during digestion),[16] and propionaldehyde (a potentially hazardous substance).[17][18][19]
Serious toxicity generally occurs only at plasma concentrations over 1 g/L, which requires extremely high intake over a relatively short period of time.[20] It would be nearly impossible to reach toxic levels by consuming foods or supplements, which contain at most 1 g/kg of PG. Cases of propylene glycol poisoning are usually related to either inappropriate intravenous administration or accidental ingestion of large quantities by children.[21] The potential for long-term oral toxicity is also low. In one study, in 1972, 12 rats were provided with feed containing as much as 5% PG in feed over a period of 104 weeks and they showed no apparent ill effects; no data on offspring was offered.[22] Because of its low chronic oral toxicity, propylene glycol was classified by the U. S. Food and Drug Administration as "generally recognized as safe" (GRAS) for use as a direct food additive.
In foods and beverages, glycerol serves as a humectant, solvent, and sweetener, and may help preserve foods. It is also used as filler in commercially prepared low-fat foods (e.g., cookies), and as a thickening agent in liqueurs. Glycerol and water are used to preserve certain types of leaves.[6] As a sugar substitute, it has approximately 27 kilocalories per teaspoon (sugar has 20) and is 60% as sweet as sucrose. It does not feed the bacteria that form plaques and cause dental cavities. As a food additive, glycerol is labeled as E number E422. It is added to icing (frosting) to prevent it setting too hard.
As used in foods, glycerol is categorized by the American Dietetic Association as a carbohydrate. The U.S. Food and Drug Administration (FDA) carbohydrate designation includes all caloric macronutrients excluding protein and fat. Glycerol has a caloric density similar to table sugar, but a lower glycemic index and different metabolic pathway within the body, so some dietary advocates accept glycerol as a sweetener compatible with low carbohydrate diets.
Benefits of Nicotine
The primary therapeutic use of nicotine is in treating nicotine dependence in order to eliminate smoking with the damage it does to health. Controlled levels of nicotine are given to patients through gums, dermal patches, lozenges, electronic/substitute cigarettes or nasal sprays in an effort to wean them off their dependence.
However, in a few situations, smoking has been observed to be of therapeutic value. These are often referred to as "Smoker’s Paradoxes".[82] Although in most cases the actual mechanism is understood only poorly or not at all, it is generally believed that the principal beneficial action is due to the nicotine administered, and that administration of nicotine without smoking may be as beneficial as smoking, without the higher risk to health due to tar and other ingredients found in tobacco.
For instance, studies suggest that smokers require less frequent repeated revascularization after percutaneous coronary intervention (PCI).[82] Risk of ulcerative colitis has been frequently shown to be reduced by smokers on a dose-dependent basis; the effect is eliminated if the individual stops smoking.[83][84] Smoking also appears to interfere with development of Kaposi's sarcoma in patients with HIV.[85][86]
Nicotine reduces the chance of preeclampsia,[87] and atopic disorders such as allergic asthma.[88][dubious – discuss] A plausible mechanism of action in these cases may be nicotine acting as an anti-inflammatory agent, and interfering with the inflammation-related disease process, as nicotine has vasoconstrictive effects.[89]
Tobacco smoke has been shown to contain compounds capable of inhibiting monoamine oxidase, which is responsible for the degradation of dopamine in the human brain. When dopamine is broken down by MAO-B, neurotoxic by-products are formed, possibly contributing to Parkinson's and Alzheimers disease.[90]
Many such papers regarding Alzheimer's disease[91] and Parkinson's Disease[92] have been published. While tobacco smoking is associated with an increased risk of Alzheimer's disease,[93] there is evidence that nicotine itself has the potential to prevent and treat Alzheimer's disease.[94] Nicotine has been shown to delay the onset of Parkinson's disease in studies involving monkeys and humans.[95][96][97] A study has shown a protective effect of nicotine itself on neurons due to nicotine activation of α7-nAChR and the PI3K/Akt pathway which inhibits apoptosis-inducing factor release and mitochondrial translocation, cytochrome c release and caspase 3 activation.[98]
Studies have indicated that nicotine can be used to help adults suffering from autosomal dominant nocturnal frontal lobe epilepsy. The same areas that cause seizures in that form of epilepsy are responsible for processing nicotine in the brain.[99]
Studies suggest a correlation between smoking and schizophrenia, with estimates near 75% for the proportion of schizophrenic patients who smoke. Although the nature of this association remains unclear, it has been argued that the increased level of smoking in schizophrenia may be due to a desire to self-medicate with nicotine.[100][101] Other research found that mildly dependent users got some benefit from nicotine, but not those who were highly dependent.[102]
Research at Duke University Medical Center found that nicotine may improve the symptoms of depression.[103] Nicotine appears to improve ADHD symptoms. Some studies have focused on benefits of nicotine therapy in adults with ADHD.[104]
While acute/initial nicotine intake causes activation of nicotine receptors, chronic low doses of nicotine use leads to desensitisation of nicotine receptors (due to the development of tolerance) and results in an antidepressant effect, with research showing low dose nicotine patches being an effective treatment of major depressive disorder in non-smokers.[105]
Nicotine (in the form of chewing gum or a transdermal patch) has been explored as an experimental treatment for OCD. Small studies show some success, even in otherwise treatment-refractory cases.[106][107][108]
The relationship between smoking and inflammatory bowel disease has been firmly established, but remains a source of confusion among both patients and doctors. It is negatively associated with ulcerative colitis but positively associated with Crohn's disease. In addition, it has opposite influences on the clinical course of the two conditions with benefit in ulcerative colitis but a detrimental effect in Crohn's disease.[109][110]
Note that most if not all of the negative affects of smoking are related to tobacco smoke. Nicotine in high concentrations is dangerous to pregnant women as it has been show to show a relation to increased birth defects, however that particular case was using gums/patches to induce the nicotine. I would say if a woman is pregnant, then she probably shouldn't use E-cigs but then, how much would a person actually be able to intake from someone using an e-sig at the next table.
The are odorless, so no nasty smell. The vapor dissipates very quickly so no cloud of smoke hanging around. No smokers hack and lung function is improved (based upon personal experience and testimonies only).
So, with all the positive benefits from E-Juice and the fact that only the nicotine has been proved in anyway to be harmful, and then only in high concentrations, what is the big deal about it? I use it for medicinal purposes even. Sounds like more idiots who want to tell others what they can and cannot do than anything that is provably harmful.
I personally use it to replace smoking. The nicotine helps with some nerve issues I have such as tremor's and involuntary muscle movements. I also use mostly mint flavors as they help with keep my sinuses working and clear (at least to the level they can function anyway).
I would totally support any FDA or similar governmental rule to label the contents, no problem. But a total ban? Go find something to do and leave us alone.