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Vaccine question

Good4Nothin

Good4Nothin

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There are two types of covid vaccines that I know of so far -- Moderna and Pfizer use mRNA technology, and Johnson & Johnson uses a de-activated virus.

Normally, as far as I know, de-activated virus vaccines use the virus that the vaccine is meant to protect against. So you would expect a covid vaccine to use the covid virus (SARS-COV-2). But it doesn't. Instead the J&J vaccine uses a chimpanzee cold virus, which is genetically modified so it can't reproduce, and so its DNA will code for the covid spike protein.

Why not just use the covid virus? Don't flu vaccines use de-activated flu viruses?

I am guessing that no one here will know. I hope I will be surprised.
 
Last edited:
Why is it not possible to delete a comment?
 
Good4Nothin said:
There are two types of covid vaccines that I know of so far -- Moderna and Pfizer use mRNA technology, and Johnson & Johnson uses a de-activated virus.

Normally, as far as I know, de-activated virus vaccines use the virus that the vaccine is meant to protect against. So you would expect a covid vaccine to use the covid virus (SARS-COV-2). But it doesn't. Instead the J&J vaccine uses a chimpanzee cold virus, which is genetically modified so it can't reproduce, and so its DNA will code for the covid spike protein.

Why not just use the covid virus? Don't flu vaccines use de-activated flu viruses?

I am guessing that no one here will know. I hope I will be surprised.
Click to expand...
The J&J vaccine uses the adenovirus as a vector to cause your cells to product a covid spike protein (or other target protein from the target virus), similar to the way the mRNA vaccines use mRNA to do so. It's actually a live virus, but totally harmless to you.
 
Good4Nothin said:
There are two types of covid vaccines that I know of so far -- Moderna and Pfizer use mRNA technology, and Johnson & Johnson uses a de-activated virus.

Normally, as far as I know, de-activated virus vaccines use the virus that the vaccine is meant to protect against. So you would expect a covid vaccine to use the covid virus (SARS-COV-2). But it doesn't. Instead the J&J vaccine uses a chimpanzee cold virus, which is genetically modified so it can't reproduce, and so its DNA will code for the covid spike protein.

Why not just use the covid virus? Don't flu vaccines use de-activated flu viruses?

I am guessing that no one here will know. I hope I will be surprised.
Click to expand...
The TL;DR answer is the mRNA technology can be tuned to address a wide variety of viruses while a technology based on sars can only address sars.
 
Good4Nothin said:
Why is it not possible to delete a comment?
Click to expand...
Admin frowns on anything being deleted. I'm guessing he's seen how other forums have abused it in the past and he doesn't want this forum damaged the way those forums were. A mod can close and 'flush' this thread if you ask.
 
Good4Nothin said:
There are two types of covid vaccines that I know of so far -- Moderna and Pfizer use mRNA technology, and Johnson & Johnson uses a de-activated virus.

Normally, as far as I know, de-activated virus vaccines use the virus that the vaccine is meant to protect against. So you would expect a covid vaccine to use the covid virus (SARS-COV-2). But it doesn't. Instead the J&J vaccine uses a chimpanzee cold virus, which is genetically modified so it can't reproduce, and so its DNA will code for the covid spike protein.

Why not just use the covid virus? Don't flu vaccines use de-activated flu viruses?

I am guessing that no one here will know. I hope I will be surprised.
Click to expand...


There are four main types of Covid 19 vaccines

www.gavi.org

There are four types of COVID-19 vaccines: here’s how they work

The fight against COVID-19 has seen vaccine development move at record speed, with more than 170 different vaccines in trials. But how are they different from each other and how will they protect us against the disease?
www.gavi.org www.gavi.org

The deactivated virus is the way Russia and China went I believe. The Moderna uses rDNA

I believe most flu vaccines use deactivated viruses as the main method
 
Tlrmln said:
The J&J vaccine uses the adenovirus as a vector to cause your cells to product a covid spike protein (or other target protein from the target virus), similar to the way the mRNA vaccines use mRNA to do so. It's actually a live virus, but totally harmless to you.
Click to expand...

I know that! Did you read my OP? I asked why they aren't using the covid virus.
 
Wayne Jr said:
The TL;DR answer is the mRNA technology can be tuned to address a wide variety of viruses while a technology based on sars can only address sars.
Click to expand...

You didn't read my OP either. I was not talking about the mRNA vaccines.
 
Wayne Jr said:
Admin frowns on anything being deleted. I'm guessing he's seen how other forums have abused it in the past and he doesn't want this forum damaged the way those forums were. A mod can close and 'flush' this thread if you ask.
Click to expand...

I don't want the thread flushed!! I had an accidental duplicate post.
 
Lord Tammerlain said:
There are four main types of Covid 19 vaccines

www.gavi.org

There are four types of COVID-19 vaccines: here’s how they work

The fight against COVID-19 has seen vaccine development move at record speed, with more than 170 different vaccines in trials. But how are they different from each other and how will they protect us against the disease?
www.gavi.org www.gavi.org

The deactivated virus is the way Russia and China went I believe. The Moderna uses rDNA

I believe most flu vaccines use deactivated viruses as the main method
Click to expand...

Why am I getting all these non-answers from people who did not read the question?

I am trying to find out why Johnson & Johnson used a chimpanzee adenovirus instead of the covid virus.
 
minnie616 said:
Sorry off topic
I have been able to delete a comment, but I don’t think one can delete a Opening post.
Click to expand...

I had a comment that was a duplicate of the OP, so I wanted to delete it. I could edit it but I could not make it go away. I've had the same problem many times on this website. You can't delete or cancel a comment.
 
Good4Nothin said:
You didn't read my OP either. I was not talking about the mRNA vaccines.
Click to expand...
I read your OP completely, and I answered your question:

Q: Why not just use the covid virus?
A: The TL;DR answer is the mRNA technology can be tuned to address a wide variety of viruses while a technology based on sars can only address sars.
 
Wayne Jr said:
I read your OP completely, and I answered your question:

Q: Why not just use the covid virus?
A: The TL;DR answer is the mRNA technology can be tuned to address a wide variety of viruses while a technology based on sars can only address sars.
Click to expand...

But Johnson & Johnson does NOT use mRNA technology! They use a virus, but not the covid virus. That was my question.
 
Good4Nothin said:
Why didn't Johnson & Johnson or AstraZeneca use the covid virus?
Click to expand...
Probably due to concerns it would not be very effective. I believe the spike proteins make using a deactivated version of coronavirus's not very effective ( I can not back that up right now)
 
Wayne Jr said:
Covid is the disease, sars is the virus that causes covid, fyi.
Click to expand...

Well that is such a silly comment. I said the covid VIRUS. I don't want to type SARS-COV-2. I DID type it once in the OP, and assumed everyone could figure out what I meant by covid virus. It is SO OBVIOUS. Unless you feel a need to nit pick.
 
Lord Tammerlain said:
Probably due to concerns it would not be very effective. I believe the spike proteins make using a deactivated version of coronavirus's not very effective ( I can not back that up right now)
Click to expand...

But why do you believe that?

I would think it would be safer to use the actual covid virus. Generating part of the spike protein can result in unintended matches, which could be disastrous.
 
Good4Nothin said:
But why do you believe that?

I would think it would be safer to use the actual covid virus. Generating part of the spike protein can result in unintended matches, which could be disastrous.
Click to expand...


For months before the current vaccines came out there was a real concern that as no effective corona virus vaccines for humans had been developed that they would fail on creating ones for Covid 19
 
Lord Tammerlain said:
For months before the current vaccines came out there was a real concern that as no effective corona virus vaccines for humans had been developed that they would fail on creating ones for Covid 19
Click to expand...

And?
 
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