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Caliber matters.
Some calibers flat out suck at creating incapacitating wounds... 25 acp for instance.
Some are better at it than others, such as .357 JHP and .45 acp. Quality hollowpoints are typically better than ball or lead in most situations.
Multiple hits are more effective than singular hits yes... but ultimately shot placement is key.
So, in my hierarchy...
1. Shot placement
2. Number of shots on target, preferably well-placed.
3. Caliber.
Not to say caliber is UNimportant just because it comes in last... they are all important. If you're using at least .38+P or better (357, 9mm, .40, 45) then this hierarchy is pretty much correct IMO. OTOH if you're using .380 or .32 or .22LR, you're using a caliber whose ability to consistently penetrate the inner body cavity and put a substantial hole in something vital is IFFY.... and caliber becomes more important.
Best of all... if possible, use a long gun. Their firepower is far greater than any handgun of comparable caliber, and their accuracy as well. About the only exception is confined spaces and close quarters, or where your piece must be concealed or carrying a long gun would be otherwise unfeasible.
Caliber can count. Number of shots on target does mean a lot. The 22s I'm using are 1470 fps advertised and verified by me with a chronograph. When you are seeing 10mm holes in the third layer of steel that round is definitely tearing up some internals. Got some right here on my desk, average 38 of the original 40 grains and consistently 10mm sharp edged discs. I'm certainly not stepping out with a subsonic hollowpoint that I haven't tested. I have a 32cal pistol as well, solids for me, hollowpoints in that caliber lack penetrating power. I'd prefer my 22 carbine over my 32 pistol. Faster, higher capacity and proven punch.