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Putin lies again. World scientists doubted the data on the Russian coronavirus vaccine.

Alfons

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World scientists doubted the data on the Russian coronavirus vaccine.

A group of physicians from Italy, the United States and other countries questioned the data on clinical trials of the Russian coronavirus vaccine.
An open letter signed by professors from a number of Italian medical faculties and universities states, among other things, suspicious similarities in the data obtained from different experiments. This letter has been published on the Cattivi Scienziati portal.
16 scientists from Italy, USA, Japan, France and Germany who signed the open letter pay attention to the duplication of some experimental values.

"There are several data templates that appear repeatedly for the described experiments. For this purpose, combining measurements for each person by time points would be very useful for reporting and therefore interpreting the results," the authors write.

In particular, 9 out of 9 volunteers who participated in one of the experiments with the vaccine, for 21 days out of 28 fully matched the antibody titers. In many cases, this is not a uniform dispersion of numbers - a common picture for clinical trials involving several volunteers, but a repetition of the same numbers in different participants of the experiments.

The authors of the letter emphasize that the data presented are too few to draw any unequivocal conclusions, but the available data also raise concerns about their unnaturalness.Yes, because all these data and figures were taken from the ceiling by Putin's liars!

source:

Note of concern

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CaughtInThe

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so he didn't lie good enough?



hahahaha
 

joluoto

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Of course he lied. No one in the international community took him seriously (there maybe was one exception) when he said Russia had a vaccine way before anyone else.
 

CaughtInThe

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didn't he "claim" to give the vaccine to one of his kids?
 

Sven Karma

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didn't he "claim" to give the vaccine to one of his kids?

Yup. Rather like when during the 'mad cow' disease furore the then UK agriculture minister made his young daughter eat a burger for the cameras to 'prove' beef was still safe to eat.
 

ThirdTerm

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The study was published in The Lancet, which is a weekly peer-reviewed medical journal. It is among the world's best-known general medical journals, too. After the Oxford vaccine's tragic failure in the phase 3 trial, the Russian vaccine may be our last hope. The author of the letter is Enrico Bucci, Adjunct Professor at Temple University, who claimed that results in Figure 2 are near identical in his blog post.

Discussion
These findings of two open, phase 1/2 non-randomised studies of a heterologous prime-boost COVID-19 vaccine based on recombinant adenoviral vectors rAd26-S and rAd5-S show that the vaccine is safe, well tolerated, and induces strong humoral and cellular immune responses in 100% of healthy participants. All reported adverse events were mostly mild. The most common systemic and local reactions were pain at the injection site, hyperthermia (body temperature 37–38°C), headache, asthenia, and muscle and joint pain, which are typical for vaccines based on recombinant viral vectors. No serious adverse events were reported during the study. In general, the adverse event profile did not differ from those reported in published work for other vector-based vaccines.25, 28, 29, 30 The incidence of adverse events in our studies was slightly lower than in other work; a comparative clinical study with other vaccines is needed to confirm these findings.

gr2.jpg

Figure 2 Humoral immune response

In preclinical studies of the vaccine (unpublished data), robust humoral and cellular immune responses were elicited in non-human primates, providing protection from SARS-CoV-2 infection. The vaccine showed 100% protectivity in a lethal model of SARS-CoV-2 challenge in immunosuppressed hamsters. No antibody-dependent enhancement of infection was seen in vaccinated and SARS-CoV-2-challenged animals.

In conclusion, these data collectively show that the heterologous vaccine based on rAd26-S and rAd5-S is safe, well tolerated, and does not cause serious adverse events in healthy adult volunteers. The vaccine is highly immunogenic and induces strong humoral and cellular immune responses in 100% of healthy adult volunteers, with antibody titres in vaccinated participants higher than those in convalescent plasma. Unprecedented measures have been taken to develop a COVID-19 vaccine in Russia. Based on our own experience in developing vaccines against Ebola virus disease and MERS, the COVID-19 vaccine has been developed in a short time. Preclinical and clinical studies have been done, which has made it possible to provisionally approve the vaccine under the current Decree of the Government of the Russian Federation of April 3, 2020, no 441 on Aug 11, 2020 (registration no LP-006395 [Gam-COVID-Vac]) and on Aug 26, 2020 (registration no LP-006423 [Gam-COVID-Vac-Lyo]). Provisional licensure requires a large-scale study, allows vaccination in a consented general population in the context of a phase 3 trial, allows the vaccine to be brought into use in a population under strict pharmacovigilance, and to provide vaccination of risk groups. The phase 3 clinical trial was approved by the appropriate national and local competent authorities, including the regulator (Department of State Regulation for Medicine Distribution) and the ethics committee of the Ministry of Health of the Russian Federation, on Aug 26, 2020 (approval 450). The phase 3 clinical trial is planned with involvement of 40 000 volunteers from different age and risk groups. The phase 3 clinical trial will be undertaken with constant monitoring of the condition of volunteers through an online application, and each dose of vaccine will have its own QR code, which will be assigned to the volunteer.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31866-3/fulltext
 
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Godric1970

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World scientists doubted the data on the Russian coronavirus vaccine.

A group of physicians from Italy, the United States and other countries questioned the data on clinical trials of the Russian coronavirus vaccine.
An open letter signed by professors from a number of Italian medical faculties and universities states, among other things, suspicious similarities in the data obtained from different experiments. This letter has been published on the Cattivi Scienziati portal.
16 scientists from Italy, USA, Japan, France and Germany who signed the open letter pay attention to the duplication of some experimental values.

"There are several data templates that appear repeatedly for the described experiments. For this purpose, combining measurements for each person by time points would be very useful for reporting and therefore interpreting the results," the authors write.

In particular, 9 out of 9 volunteers who participated in one of the experiments with the vaccine, for 21 days out of 28 fully matched the antibody titers. In many cases, this is not a uniform dispersion of numbers - a common picture for clinical trials involving several volunteers, but a repetition of the same numbers in different participants of the experiments.

The authors of the letter emphasize that the data presented are too few to draw any unequivocal conclusions, but the available data also raise concerns about their unnaturalness.Yes, because all these data and figures were taken from the ceiling by Putin's liars!

source:

Note of concern

MJ5qpIoDYsK4rOAzBQEWgUyj1MjWo0cbK1tn-qUoc-qsJIehC6GWPd7egfybpmkKjO8R4votISPhVST1c93GArw0EmKtUdnRBXQer8j_Clrefun3ICVd7HoiaA

i think you will find the Lancet has way more credibility than a bunch of random doctors
 
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