New Drug with Promising Results

[humbolt]

I'm not sure what you mean by 'endorsed' but it doesn't appear they've made any claims it actually works.

ATS Publishes New Guidance on COVID-19 Management

Their word, not mine.

 

[Herkamer63]

I, for one, am glad that new and existing drugs are working as good treatment options. Whatever can help the body build an immunity to stuff like this I'm cool with.

 

[humbolt]

Chloro effective for what? It is not expected nor designed by the trial guidelines to be tested for purposes of cure or vaccine. You asking that if chloro were to be a cure and/or a vaccine isn’t even in the ballpark. What if an apple a day or laetrile were found to be a cure or vaccine? If a tablespoon of cod live oil or cow pie were found to be a cure, it would be administered and business would open up and people would be back to work sooner.


What delay? I’ve not heard of any in NY. Brazil stopped their chloro testing because too many patients were developing irregular heart rhythm, a condition most susceptible to hear attack as a “side effect” of chloro.

You’re asking me for information you should have researched yourself. Obviously, your entire post indicates you didn’t do your homework and I’m not going to do it for you. If you are claiming that Cuomo has not yet started the study, say so. You did claim Cuomo was “delaying the trials”, but give no evidence, making your claim unfounded unless you provide evidence of any significant, unjustified delay.

You can take whatever you like. If I find myself with a virus induced pneumonia, I'll take the chloroquine unless something better is available. It has nothing to do with what Trump did or didn't say, or what Trump might say. It's about survival.

 

[bluesmoke]

You can take whatever you like. If I find myself with a virus induced pneumonia, I'll take the chloroquine unless something better is available. It has nothing to do with what Trump did or didn't say, or what Trump might say. It's about survival.

It isn't a matter of something better. Chloro isn't in the range of any baseline to determine what is better or not. Chloro is no more proved as a cure/vaccine than an apple a day, laetrile, cod live oil, cow pie extract or prayer. AND, chloro is NOT being tested as a remedy to save life. That trial use was not approved by the FDA.

 

[humbolt]

It isn't a matter of something better. Chloro isn't in the range of any baseline to determine what is better or not. Chloro is no more proved as a cure/vaccine than an apple a day, laetrile, cod live oil, cow pie extract or prayer. AND, chloro is NOT being tested as a remedy to save life. That trial use was not approved by the FDA.

Heh. As I said, you can take what you like. Until something better shows up, I'll take the chloroquine if I need to. If it holds death at bay, I'll consider it life-saving. You can consider it a coincidence if you like.

 

[Threegoofs]

Heh. As I said, you can take what you like. Until something better shows up, I'll take the chloroquine if I need to. If it holds death at bay, I'll consider it life-saving. You can consider it a coincidence if you like.

Hydroxychloroquine is better than chloroquine. At least in the tox profile.

Probably equivalent in efficacy- zero.

But you don’t think you need to know the difference.

 

[humbolt]

Hydroxychloroquine is better than chloroquine. At least in the tox profile.

Probably equivalent in efficacy- zero.

But you don’t think you need to know the difference.

Lecture your fellow political travelers on it. One of them recently referred to it as "chloro". Personally, I know what she meant. You seem to be the one having difficulty here.

 

[bluesmoke]

Heh. As I said, you can take what you like. Until something better shows up, I'll take the chloroquine if I need to. If it holds death at bay, I'll consider it life-saving. You can consider it a coincidence if you like.

Just take your sugar pills and be happy. You don't have to consider placebo a coincidence, but rather a cure, if you like.

 

[Gladiator]

Just take your sugar pills and be happy. You don't have to consider placebo a coincidence, but rather a cure, if you like.

"Based on a back-of-the-envelope analysis combining two studies of the clinical progression of COVID-19, roughly 9 percent of severe cases become critical, and approximately 3 percent of patients with severe symptoms die. These numbers indicate that of the 113 cases in the Chicago trial, around four were likely to die without a therapeutic. Two patients have died, which, albeit an apparent improvement, suggests only a statistically insignificant impact. That doesn’t undermine the efficacy of RDV; the sample sizes are small, and numerous unobserved variables affect medical outcomes. But that’s the point: It’s hard to conclude very much from compassionate-use studies."

Coronavirus Pandemic: Gilead's Remdesivir Clinical Trials Inconclusive | National Review

//

 

[bluesmoke]

"Based on a back-of-the-envelope analysis combining two studies of the clinical progression of COVID-19, roughly 9 percent of severe cases become critical, and approximately 3 percent of patients with severe symptoms die. These numbers indicate that of the 113 cases in the Chicago trial, around four were likely to die without a therapeutic. Two patients have died, which, albeit an apparent improvement, suggests only a statistically insignificant impact. That doesn’t undermine the efficacy of RDV; the sample sizes are small, and numerous unobserved variables affect medical outcomes. But that’s the point: It’s hard to conclude very much from compassionate-use studies."

Coronavirus Pandemic: Gilead's Remdesivir Clinical Trials Inconclusive | National Review

//

At least RDV is a legit trial. Chloro was/is not, even for it's more limited scope than RDV.

 

[Luckyone]

New results from remsidivir came out today

Gilead says shorter remdesivir regimen is effective and drug met main goal in government study
Published: April 29, 2020 at 8:57 a.m. ET

Gilead Sciences Inc. GILD, -1.53% on Wednesday morning announced data from two clinical trials testing its experimental drug remdesivir in severely ill COVID-19 patients. The drugmaker's stock was halted in premarket trading on Wednesday in advance of company disclosures about remdesivir's performance in the studies. Gilead said an open-label Phase 3 trial testing the therapy in severely ill patients found that those taking a 5-day or 10-day course of treatment led to similar results. At least 52% of participants taking either dosing regimen were discharged from the hospital after 14 days of treatment, and at least 53% of those patients were reported as reaching "clinical recovery." "Multiple concurrent studies are helping inform whether remdesivir is a safe and effective treatment for COVID-19," Gilead chief medical officer Merdad Parsey said in a statement. "The study demonstrates the potential for some patients to be treated with a 5-day regimen, which could significantly expand the number of patients who could be treated with our current supply of remdesivir." Minutes before this topline data was released, Gilead also said that a government-run clinical trial evaluating remdesivir in severely ill COVID-19 patients met the study's primary endpoint.

 

[Threegoofs]

New results from remsidivir came out today

Not the most stellar announcement.

Sounds like an open label trial looks good (but open label isn’t optimal) and the other trial had no control- just showed a short course I’d as good as a longer course.

But that’s exactly what you’d expect to see if neither course worked.

 

[snakestretcher]

It's a problem if Trump mentions it as a reason to go back to business as usual.

The French did ultimately save our Revolutionary asses.

They did indeed; without the French money, arms, troops and ships that Franklin went begging for, the outcome would have been very different. France saw it as a great way to have a poke back at England.

 

[Threegoofs]

Hmm.

Regarding remdisivir news:

Gilead: Critical study of Covid-19 drug shows patients respond to treatment

This says the study (from NIAID) has a placebo control- but the press release says it was open label. But it was 800 patients - which is great. It also says it was blinded, which would be definitive.

I’m guessing it’s a control group with no drug, which means the remdisivir data is definitely not optimal, but suggestive.
Even stronger if it was randomized, which I assume it was.

 

[bluesmoke]

They did indeed; without the French money, arms, troops and ships that Franklin went begging for, the outcome would have been very different. France saw it as a great way to have a poke back at England.

Saved by some 18 yr-old dude named Gilbert du Motier, the Marquis de La Fayette, who also directed American troops in several battles. Then, he went back to France and was instrumental in the 1789 French Revolution. Hilarious. One of my favorite historical figures.

 

[Rogue Valley]

Trump can mention cures but he then has to turn it over to the medical experts to support it. He is no doctor!