A vaccine on the near horizon?

[OldFatGuy]

Pittsburgh scientists develop possible coronavirus vaccine, hope FDA can fast-track it | TribLIVE.com

The FDA is meeting tomorrow morning to discuss fast tracking this within 2 months of processing to manufacture, suggesting manufacture commence before approval. There is no link for this info, however an internal memo issued late this afternoon at Johnson & Johnson delineated a chain of command for beginning manufacture subsequent to the FDA meeting.

 

[Casper]

Pittsburgh scientists develop possible coronavirus vaccine, hope FDA can fast-track it | TribLIVE.com

The FDA is meeting tomorrow morning to discuss fast tracking this within 2 months of processing to manufacture, suggesting manufacture commence before approval. There is no link for this info, however an internal memo issued late this afternoon at Johnson & Johnson delineated a chain of command for beginning manufacture subsequent to the FDA meeting.

Don't count on seeing one in 2 months, even fast tracking it still includes a lot of testing and an approval process. Once approved it must be produced and distributed, they need 377,000,000 doses to cover the population. All takes time and those with health conditions and those over 60 will get the vaccine first. MAYBE by the end of the year.

 

[yankintx]

No vaccine is going to get us out of this current mess. Sure maybe in a year, quite possibly 9 months. There is no miracle coming folks this time around.

 

[JANFU]

Pittsburgh scientists develop possible coronavirus vaccine, hope FDA can fast-track it | TribLIVE.com

The FDA is meeting tomorrow morning to discuss fast tracking this within 2 months of processing to manufacture, suggesting manufacture commence before approval. There is no link for this info, however an internal memo issued late this afternoon at Johnson & Johnson delineated a chain of command for beginning manufacture subsequent to the FDA meeting.

You are aware that animal testing has been sidelined?

 

[iguanaman]

No vaccine is going to get us out of this current mess. Sure maybe in a year, quite possibly 9 months. There is no miracle coming folks this time around.

Not from a vaccine that's for sure but there is still hope that an effective treatment might still come in time to save some lives.

 

[swing_voter]

There's like a dozen different companies who have a vaccine in testing.

 

[OldFatGuy]

Don't count on seeing one in 2 months, even fast tracking it still includes a lot of testing and an approval process. Once approved it must be produced and distributed, they need 377,000,000 doses to cover the population. All takes time and those with health conditions and those over 60 will get the vaccine first. MAYBE by the end of the year.

Ye of little faith. There is an American motto, "Can do."

Sit back, be a critic announcing hopelessness for those who will die, or get off that derriere and do something positive instead of whining.

Perhaps instead of distributing a vaccine to the most vulnerable first, we should use a lottery system to make you happy? And wrong we don't need 377 million doses, we need more than 7.53 billion doses.

It would not be a miracle, it would be a risk and hard work.

 

[OldFatGuy]

You are aware that animal testing has been sidelined?

Are you aware that might save your life?

 

[Daisy]

Nope...not gonna happen that soon...

 

[OldFatGuy]

"All these negative vibes, man." - Sgt. Oddball

 

[Visbek]

Ye of little faith. There is an American motto, "Can do."

C'mon, man.

Once we have a vaccine, it will need to be distributed hundreds of millions of people just in America. Billions of people will need the vaccine.

That means we cannot take shortcuts. We need to be sure that it is effective and safe. That's why even if they develop a vaccine in the next five minutes, it will take at least a year before it can be widely distributed.

 

[Casper]

Ye of little faith. There is an American motto, "Can do."

Sit back, be a critic announcing hopelessness for those who will die, or get off that derriere and do something positive instead of whining.

Perhaps instead of distributing a vaccine to the most vulnerable first, we should use a lottery system to make you happy? And wrong we don't need 377 million doses, we need more than 7.53 billion doses.

It would not be a miracle, it would be a risk and hard work.

Not of little faith, just realistic.
Not being a critic, just explaining how this works, do you want them to rush something through that does not work or can do harm?
I follow the guidelines religiously, sorry to disappoint ya but there really is nothing else those of us not in the medical field can do.
I agree with giving those most at risk any available vaccine first, I never said different.
Seems my post triggered you so I believe this discussion is finished. I won't even come back in two months and tell you I told you so.
Good Day, Be Safe

 

[OldFatGuy]

C'mon, man.

Once we have a vaccine, it will need to be distributed hundreds of millions of people just in America. Billions of people will need the vaccine.

That means we cannot take shortcuts. We need to be sure that it is effective and safe. That's why even if they develop a vaccine in the next five minutes, it will take at least a year before it can be widely distributed.

There is nothing to stop a general release of the data for creating the vaccine so every nation can use or build their own labs to produce it, except greed. Ask a patient with stage 4 cancer about hope vs safe. How many companies are now producing ventilators? Of course we can take shortcuts.

I am a human guinea pig for medical research. Without volunteering to do so, I'd be bedridden at the least, or dead. All protocols are being ignored. Instead I'm pleasing myself by making music every day and cooking for 14 or more, as well as doing the food shopping, taking long walks with my dog and making love to my wife. The FDA said no, my lawyers said yes. So it goes.

 

[Mach]

C'mon, man.

Once we have a vaccine, it will need to be distributed hundreds of millions of people just in America. Billions of people will need the vaccine.

That means we cannot take shortcuts. We need to be sure that it is effective and safe. That's why even if they develop a vaccine in the next five minutes, it will take at least a year before it can be widely distributed.

Still a good article. They mentioned changes to regulations that will help speed it up, a move to production while still in testing, as well as aspects of their vaccine they feel makes it inherently safer. Smaller amounts of antigen than in traditional flu vaccinations. Also delivery is just under the skin using 400 micro needles, like a scratch method. Meaning, according to them, it Is necessarily less likely to cause systemic side effects like in flu vaccines. Not saying I think we will hit sub 12 months...just have to imagine we will advance this over months, similar to how everything else is having to change. Except ignorant people still not understanding the severity. That seems to be a guarantee.

 

[Helix]

a novel vaccine is 12 to 18 months minimum from what i've read in the news. if something comes out sooner, it's probably because it's an already partially developed vaccine that they have discovered provides some level of protection. it's possible, i hope.

 

[Hawkeye10]

Pittsburgh scientists develop possible coronavirus vaccine, hope FDA can fast-track it | TribLIVE.com

The FDA is meeting tomorrow morning to discuss fast tracking this within 2 months of processing to manufacture, suggesting manufacture commence before approval. There is no link for this info, however an internal memo issued late this afternoon at Johnson & Johnson delineated a chain of command for beginning manufacture subsequent to the FDA meeting.

There has never been a vaccine for coronavirus, and I am told that this BUG is not easy...

Call me skeptical.

:2wave:

 

[OldFatGuy]

There has never been a vaccine for coronavirus, and I am told that this BUG is not easy...

Call me skeptical.

:2wave:

It hasn't been around for that long. No need for a vaccine. Basically it is a variant of the cold virus. We have not been able to cure the common cold because if constantly mutates by almost imperceptible variations, thus multiples of strains. Similar behavior to flu viruses. We develop flu vaccines that only address a percentage of the mutated variations, strains. Covoid 19 has been identified as 4 different strains, 3 predatory for humans, and not very dissimilar from SARS and HIV in basic structure. Most vaccines work by getting the immune system to create and replicate antibodies which prey on the targeted virus. Not very easy when there is little understanding of how the virus replicates. Duplicating a virus in a lab, does not necessarily mean that there is an understanding of the viral replication mechanisms. Therefore providing instructions for antibody structures is difficult at the least. Almost incidental when it occurs.

It took a decade to identify the various polio strains before truly effective use was acceptable. First resolved in 1946 and used on a human researcher injecting himself but not released for general use until 1955, and then withdrawn temporarily for an assortment of reasons. Despite how much we've learned about viruses, there is much more we do not know. None which means this particular vaccine cannot be fast tracked and distributed like no other previously. Necessity is the mother of invention.

Maybe it will work, maybe it won't, perhaps it will be worse than the disease? Nothing ventured, nothing gained. No pain, no gain. How many of the dying will volunteer for its use? Now let all the experts chime in.

 

[apdst]

"All these negative vibes, man." - Sgt. Oddball

They got to play it for all it's worth. At least until November.

 

[jamesbyoung]

The trials, if approved, can begin in two months but it will be June or July of next year before a full population vax can be approved.

 

[TurtleDude]

They got to play it for all it's worth. At least until November.

Some see the virus as the cure to the thing that vexes them most-Trump in the White House.

 

[RAMOSS]

Don't count on seeing one in 2 months, even fast tracking it still includes a lot of testing and an approval process. Once approved it must be produced and distributed, they need 377,000,000 doses to cover the population. All takes time and those with health conditions and those over 60 will get the vaccine first. MAYBE by the end of the year.

One group said that IF testing goes well, they expect to give the vaccine for 'compassionate care' by Sept 30th. (mind you, the cravat is the testing for it).

 

[RAMOSS]

a novel vaccine is 12 to 18 months minimum from what i've read in the news. if something comes out sooner, it's probably because it's an already partially developed vaccine that they have discovered provides some level of protection. it's possible, i hope.

One company basically took the vaccine they developed for Sars, and 'evolved it' for covid 19. SO, it was modifying something they had already.

 

[Hawkeye10]

It hasn't been around for that long. No need for a vaccine. Basically it is a variant of the cold virus. We have not been able to cure the common cold because if constantly mutates by almost imperceptible variations, thus multiples of strains. Similar behavior to flu viruses. We develop flu vaccines that only address a percentage of the mutated variations, strains. Covoid 19 has been identified as 4 different strains, 3 predatory for humans, and not very dissimilar from SARS and HIV in basic structure. Most vaccines work by getting the immune system to create and replicate antibodies which prey on the targeted virus. Not very easy when there is little understanding of how the virus replicates. Duplicating a virus in a lab, does not necessarily mean that there is an understanding of the viral replication mechanisms. Therefore providing instructions for antibody structures is difficult at the least. Almost incidental when it occurs.

It took a decade to identify the various polio strains before truly effective use was acceptable. First resolved in 1946 and used on a human researcher injecting himself but not released for general use until 1955, and then withdrawn temporarily for an assortment of reasons. Despite how much we've learned about viruses, there is much more we do not know. None which means this particular vaccine cannot be fast tracked and distributed like no other previously. Necessity is the mother of invention.

Maybe it will work, maybe it won't, perhaps it will be worse than the disease? Nothing ventured, nothing gained. No pain, no gain. How many of the dying will volunteer for its use? Now let all the experts chime in.

We shall see,,,as you know well I am willing to consider alternative ideas and opinions...I am high in openness as all of The Better People know.... but here is the thing....almost all of the people who have experienced this Bug have promptly crapped their pants...

What am I to make of that?

 

[OldFatGuy]

We shall see,,,as you know well I am willing to consider alternative ideas and opinions...I am high in openness as all of The Better People know.... but here is the thing....almost all of the people who have experienced this Bug have promptly crapped their pants...

What am I to make of that?

My son tells me he and his colleagues have encountered infected patients with few or no symptoms, some of them being high risk from other problems. He has also said the worst sufferers, for the most part, seem to be blood type A, which may or may not be a factor. He also mentioned inability to metabolize specific vitamins, but no certainty of before or after. We didn't have time to get into details, he wanted to know how his kids were doing, and of course I told him they are a PITA. Got a chuckle. He's the father of the twins and hasn't seen them for two weeks. He and his wife, an RN, are staying at first class hotel, which belongs to one of my longtime friends. On the cuff, along with about 20 other doctors and 30 or so nurses. Unfortunately, they can't enjoy it, just coming back to their rooms with take out, showering, changing and passing out from exhaustion before going back to work. His wife makes a point of speaking with the kids once a day, he doesn't have that luxury. There older kids have been in and out for meals, checking on siblings and cousins, volunteering with meals on wheels, delivering meds, and similar activities. Good kids.

 

[OldFatGuy]

The trials, if approved, can begin in two months but it will be June or July of next year before a full population vax can be approved.

Not a time for older established restrictions. I'd have thought the progressives would celebrate the cutting of red tape.