Ozzy Osbourne’s Genes Really Were Wired for Alcohol and Addiction

[Chock Full o Nuts]

Looks like he was built for abuse that would have killed a normal man!

Ozzy Osbourne’s Genes Really Were Wired for Alcohol and Addiction

His genome held strange secrets: a turbocharged alcohol gene, rewired brain chemistry, and a slow-burn caffeine receptor.

www.zmescience.com

Ozzy Osbourne shouldn’t have survived.

He said it. The scientists said it. Anyone who watched him howl into a microphone with a bat in one hand and a bottle of cognac in the other said it. And yet, for more than five decades, Osbourne defied every expectation. He drank, smoked, injected, snorted, crashed, stumbled, and still—miraculously—showed up.

But in 2010, Ozzy joined an elite, if unlikely, group: the first rock star to have his entire genome sequenced. He dived into the uncharted world of celebrity genomics. His reasoning was pure metal:

“I was curious,” he explained. “Given the swimming pools of booze I’ve guzzled over the years—not to mention all of the cocaine, morphine, sleeping pills, cough syrup, LSD, Rohypnol…you name it—there’s really no plausible medical reason why I should still be alive. Maybe my DNA could say why.”

The ADH gene family encodes alcohol dehydrogenase enzymes, which are responsible for the primary metabolic breakdown of alcohol in the liver and stomach. Osbourne appeared to have a unique mutation variation near this gene that body to produce the ADH4 protein more efficiently, allowing him to metabolize alcohol significantly faster than the average person.

He carried two rare versions of CLTCL1, a gene that affects how cells absorb and recycle material, a process critical for neurons. The variant made a “grossly different” version of the protein, according to the genetic report. This gene helps nerve cells communicate. And in Ozzy, the system looked unusually rewired.

 

[dseag2]

Really interesting study.

 

[Jessie C]

Looks like he was built for abuse that would have killed a normal man!

Ozzy Osbourne’s Genes Really Were Wired for Alcohol and Addiction

His genome held strange secrets: a turbocharged alcohol gene, rewired brain chemistry, and a slow-burn caffeine receptor.

www.zmescience.com

This analogy very accurately portrays his metabolic psyche. Most humans woud never survive the abuse he subjcted his body to. Ozzy has his permanent place in this world that will never be forgotton.