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Eugenics

Lord Tammerlain said:
Almost nothing is 100-% when it comes to genetics

To my limited knowledge only if all four grandparents had the genetic trait and passed it on to their child/s then those two children would generally have a close to 100% chance of passing it on to their child.

As we normally get half of our chromosomes from each parent, only if both parents had on each side of their chromosomes would the child have a near 100% chance of getting the genetically passed down disease.

Which is why inbreeding is generally bad, genetic diseases don’t get “ filtered “ out
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Even then it would depend on whether the trait is dominant or recessive, but for a dominant trait you usually don't need all four for it to pass. And it could also pass unseen. For example blue eyes is a recessive trait. You could have brown eyes (which is a dominant trait) and still have the genes for the recessive trait and pass it on.
 
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