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Progress Toward A Safer Psychedelic Drug To Treat Depression And Addiction

JacksinPA

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A chemically tweaked version of the psychedelic drug ibogaine appears to relieve depression and addiction symptoms without producing hallucinations or other dangerous side effects.

The results of a study in rodents suggest it may be possible to make psychedelic drugs safe enough to become mainstream treatments for psychiatric disorders, the authors report Wednesday in the journal Nature.

"What we need is a medicine that is so safe that you can take it home and put it in your medicine cabinet just like you would aspirin," says David Olson, the paper's senior author and an assistant professor at the University of California, Davis. "And that's really what we were trying to achieve."

The success with ibogaine is "a promising first step," says Gabriela Manzano, a postdoctoral fellow at Weill Cornell Medicine in New York and a co-author of a commentary on the study.
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I've been fascinated by psychedelic drugs since the 60s. Ibogaine is very interesting as both a hallucinogen & a powerful mind-altering drug that has been used in clinical settings to relieve addiction for years.
 

Chomsky

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Interesting. Ibogaine has been used to treat heroin addicts, in the past.
 

JacksinPA

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Interesting. Ibogaine has been used to treat heroin addicts, in the past.

I think the referenced reeningeering of ibogaine is to damp down the psychedelic symptoms of the natural product.

Interesting chemical. I've read of psychedelic research & addiction treatment near the source of the natural product in Africa.

Publication (not sure if connected):


Modified Ibogaine Fragments:  Synthesis and Preliminary Pharmacological Characterization of 3-Ethyl-5-phenyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]benzothiophenes


Cite this: J. Med. Chem. 1998, 41, 23, 4486–4491
Publication Date:September 30, 1998
https://doi.org/10.1021/jm980156

Journal of Medicinal Chemistry
Abstract
Five phenyl-substituted derivatives and analogues of 1,2,3,4,5,6-hexahydroazepino[4,5-b]indole, 5, a major fragment of ibogaine (1), were synthesized and tested for binding to monoamine transporters, the NMDA receptor-coupled cation channel, and dopamine and opioid receptors. All five derivatives, 9 and 17a−d, displayed 8−10-fold higher affinity at the DA transporter than ibogaine and noribogaine (4). At the serotonin transporter, two compounds (9 and 17a) exhibited higher potency than ibogaine, while the rest had weaker binding affinities than the lead compound. In keeping with their structural similarity to ibogaine, all five compounds displayed weak to poor affinity for dopamine D1 and D2 receptors. However, two compounds, 17a,c, demonstrated moderate binding affinities at dopamine D3 receptors. All five compounds displayed weak to poor affinities for μ and κ opioid receptors and for the NMDA receptor-coupled cation channel. Despite the qualitative differences, derivatives and analogues of 5 may serve as useful substitutes for ibogaine.
 
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GDViking

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Timothy Leary and Albert Hoffman documented incredible success treating physiological issues in their research.

Worked from one level to another on everything except narcissism...
 
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