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Newly discovered cells in mice can sense four of the five tastes


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Newly discovered cells in mice can sense four of the five tastes | Science News

By pulling taste cells out of the bud, scientists found a set that can taste broadly

Taste buds can turn food from mere fuel into a memorable meal. Now researchers have discovered a set of supersensing cells in the taste buds of mice that can detect four of the five flavors that the buds recognize. Bitter, sweet, sour and umami — these cells can catch them all.

That’s a surprise because it’s commonly thought that taste cells are very specific, detecting just one or two flavors. Some known taste cells respond to only one compound, for instance, detecting sweet sucralose or bitter caffeine. But the new results suggest that a far more complicated process is at work.

When neurophysiologist Debarghya Dutta Banik and colleagues turned off the sensing abilities of more specific taste cells in mice, the researchers were startled to find other cells responding to flavors. Pulling those cells out of the rodents’ taste buds and giving them a taste of several compounds revealed a group of cells that can sense multiple chemicals across different taste classes, the team reports August 13 in PLOS Genetics.

“We never expected that any population of [taste] cells would respond to so many different compounds,” says Dutta Banik, of the Indiana University School of Medicine in Indianapolis.

But taste cells don’t respond to flavors in insolation; the brain and the tongue work together as tastemakers (SN: 11/24/15). So the scientists monitored the brain to see if it received bitter, sweet or umami signals when mice lacked a key protein needed for these broadly tasting cells to relay information. Those observations revealed that without the protein, the brain didn’t get the flavor messages, which was also shown when mice slurped bitter solutions as though they were water even though the rodents hate bitter tastes, says Dutta Banik, who did the work at the University at Buffalo in New York.

While these broadly sensing cells were incommunicado, the brain also seemed to miss signals from other more specific taste cells, such as those for sensing bitterness. So it may be that the broadly sensing cells work with the others to communicate taste information.

“The presence of these [newly discovered] cells completely disrupts how people think the taste bud works,” says Kathryn Medler, a neurophysiologist at the University at Buffalo.
Neurophysiology has a lot of unexplored & surprising features
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