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I was clearly wrong.
If any part of "The Aviator" is to be trusted as even partially based on factual biographical details of Howard's life, we can then state that Howard Hughes suffered a massive case of OCD driven germophobia based on the Spanish Flu epidemic of 1918, which is now suspected to have been an ancient form of SARS and not really influenza.
If we go on that, we can expand a historical view of how the epidemic tortured the psyche of millions around the world, just as The Black Death did in the Dark Ages.
It's a safe bet that, thanks to the rabble rousing from the COVID anti-vaccine extremists, we will be hearing this nonsense for several generations hence, just as we heard evil twisted nursery rhymes based on millennia old plagues, NO SPITTING signs on city streets and legions of paranoiacs running around based on 1918 sanitary laws in reaction to the epidemic of that time.